Cell biological analysis through direct microscopic observation has adopted molecular biological techniques to study the expression of particular genes. With antibodies and other molecular probes, the specific subcellular localization of a given type of protein can readily be visualized using conventional light microscopes, Confocal microscopes and electron microscopes. A tremendous amount of information has been reported on the synthesis, processing and transport of many classes of proteins resulting from the direct visualization of protein expression in the tissue. Recently, the specific subcellular localization of mRNA transcripts has been reported in several systems relating the localization of the RNA to the localization and function of the proteins they encode (Garner, et al., 1988; Macdonald and Struhl, 1988; Singer, et al., 1989; Yisraeli and Melton, 1988, 1990; Pollock et al., 1990). The success of these studies have relied on the large physical dimensions of the cells used so that the non-isotopic, light microscopic techniques employed could resolve distinct regional differences in the RNA signal.